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Meg Ryan has published a heartfelt tribute to the late filmmaker Rob Reiner, who directed her in the beloved romantic comedy When Harry Met Sally.

A Tragic Discovery

Reiner was found dead with his wife, Michele Singer Reiner, at their Los Angeles home over the weekend.

“We will miss this man so deeply…” Ryan shared on Instagram, next to an image of them together. “Our gratitude, Rob and Michele, for your faith in true love, stories, and joy. We appreciate your faith in human goodness and your deep patriotism.”

Charges Filed

Reiner’s son Nick, 32, is accused of two counts of first-degree murder and appeared in court today. He’s being held without bail. It’s been reported that Reiner’s daughter Romy discovered her father deceased.

“I must hold onto hope that their tale doesn't conclude here, that awareness can be heightened from this,” Ryan continued. “I don’t know, but my guess is that they would want that to be hopeful and humane, to be something that brings us all to a greater understanding of one another and to some peace.”

Family Members Issue a Message

Reiner’s other children Jake and Romy issued words today. “Words cannot even begin to describe the unimaginable pain we are experiencing every moment of the day,” they said. “The horrific and devastating loss of our parents, Rob and Michele Reiner, is something that no one should ever experience. Beyond being our mom and dad, they were our dearest friends.”

Colleagues and Friends Remember

Ryan’s co-star, Billy Crystal, joined in remembering Reiner via comments shared yesterday alongside tributes from Larry David, Martin Short and Albert Brooks.

“His skill for comedy was unmatched, his ear for dialogue perfect, and his dramatic precision was sheer elegance,” it read. “He adored his actors. He elevated his writers. Freedom was his key offering. He listened to ideas and included you in the creative journey. Collaborators felt like a unified team. Being guided by him was an honor, yet just one facet of his impact.”

A Storied Career

When Harry Met Sally was a hit with both critics and audiences in 1989, grossing more than $93 million worldwide and securing Nora Ephron an Oscar nomination for best original screenplay.

Rob Reiner met Michele Singer Reiner while making When Harry Met Sally. The pair were brought together by Barry Sonnenfeld, a director and friend.

Reiner’s notable filmography also included classics such as Misery, Stand by Me and The Princess Bride. The director and his wife were husband and wife for over three decades.